Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035502-06
Application #
6230395
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Plaeger, Susan F
Project Start
1994-08-01
Project End
2003-07-31
Budget Start
1999-11-01
Budget End
2001-07-31
Support Year
6
Fiscal Year
2000
Total Cost
$488,369
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Elliott, Sarah T C; Riddick, Nadeene E; Francella, Nicholas et al. (2012) Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5. J Virol 86:898-908
Loftin, Lamorris M; Kienzle, Martha; Yi, Yanjie et al. (2011) R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies. J Transl Med 9 Suppl 1:S3
Riddick, Nadeene E; Hermann, Emilia A; Loftin, Lamorris M et al. (2010) A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. PLoS Pathog 6:e1001064
Loftin, Lamorris M; Kienzle, Martha F; Yi, Yanjie et al. (2010) Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry. Virology 402:135-48
Isaacman-Beck, Jesse; Hermann, Emilia A; Yi, Yanjie et al. (2009) Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization. J Virol 83:8208-20
Yi, Yanjie; Loftin, Lamorris; Wang, Lingshu et al. (2008) Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection. J Acquir Immune Defic Syndr 47:285-92
Malik, Mobeen; Chen, Ying-Yu; Kienzle, Martha F et al. (2008) Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase. J Immunol 181:4632-7
Cheung, Ricky; Ravyn, Vipa; Wang, Lingshu et al. (2008) Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. J Immunol 180:6675-84
Lee, B; Doranz, B J; Rana, S et al. (1998) Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4. J Virol 72:7450-8