Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035545-03
Application #
2071293
Study Section
Special Emphasis Panel (SRC (82))
Project Start
1993-11-01
Project End
1997-10-31
Budget Start
1995-11-01
Budget End
1996-10-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Miller, Christopher J; Lu, Fabien X (2003) Anti-HIV and -SIV immunity in the vagina. Int Rev Immunol 22:65-76
Lena, P; Villinger, F; Giavedoni, L et al. (2002) Co-immunization of rhesus macaques with plasmid vectors expressing IFN-gamma, GM-CSF, and SIV antigens enhances anti-viral humoral immunity but does not affect viremia after challenge with highly pathogenic virus. Vaccine 20 Suppl 4:A69-79
Abel, Kristina; Alegria-Hartman, Michelle J; Rothaeusler, Kristina et al. (2002) The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection. J Virol 76:8433-45
Marthas, M L; Lu, D; Penedo, M C et al. (2001) Titration of an SIVmac251 stock by vaginal inoculation of Indian and Chinese origin rhesus macaques: transmission efficiency, viral loads, and antibody responses. AIDS Res Hum Retroviruses 17:1455-66
Greenier, J L; Miller, C J; Lu, D et al. (2001) Route of simian immunodeficiency virus inoculation determines the complexity but not the identity of viral variant populations that infect rhesus macaques. J Virol 75:3753-65
Abel, K; Alegria-Hartman, M J; Zanotto, K et al. (2001) Anatomic site and immune function correlate with relative cytokine mRNA expression levels in lymphoid tissues of normal rhesus macaques. Cytokine 16:191-204
Huang, Y T; Miller, C J; Wong, V et al. (1999) Replication and budding of simian immunodeficiency virus in polarized epithelial cells. Virology 257:24-34
Miller, C J; Hu, J (1999) T cell-tropic simian immunodeficiency virus (SIV) and simian-human immunodeficiency viruses are readily transmitted by vaginal inoculation of rhesus macaques, and Langerhans' cells of the female genital tract are infected with SIV. J Infect Dis 179 Suppl 3:S413-7
Lu, X; Kiyono, H; Lu, D et al. (1998) Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251. AIDS 12:1-10
McChesney, M B; Collins, J R; Lu, D et al. (1998) Occult systemic infection and persistent simian immunodeficiency virus (SIV)-specific CD4(+)-T-cell proliferative responses in rhesus macaques that were transiently viremic after intravaginal inoculation of SIV. J Virol 72:10029-35

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