Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035763-03
Application #
2071672
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1994-05-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brown University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Braastad, Corey D; Han, Zhiyong; Hendrickson, Eric A (2003) Constitutive DNase I hypersensitivity of p53-regulated promoters. J Biol Chem 278:8261-8
Li, Gang; Nelsen, Caron; Hendrickson, Eric A (2002) Ku86 is essential in human somatic cells. Proc Natl Acad Sci U S A 99:832-7
Braastad, Corey D; Leguia, Mariana; Hendrickson, Eric A (2002) Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. Nucleic Acids Res 30:1713-24
Han, Zhiyong; Wei, Wenyi; Dunaway, Stephen et al. (2002) Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J Biol Chem 277:17154-60
Han, Z; Pantazis, P; Wyche, J H et al. (2001) A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. J Biol Chem 276:38748-54
Han, Z; Bhalla, K; Pantazis, P et al. (1999) Cif (Cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid. Mol Cell Biol 19:1381-9
Myung, K; Braastad, C; He, D M et al. (1998) KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion. Proc Natl Acad Sci U S A 95:7664-9
Han, Z; Li, G; Bremner, T A et al. (1998) A cytosolic factor is required for mitochondrial cytochrome c efflux during apoptosis. Cell Death Differ 5:469-79
Errami, A; He, D M; Friedl, A A et al. (1998) XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucleic Acids Res 26:3146-53
Wang, J; Dong, X; Myung, K et al. (1998) Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding. J Biol Chem 273:842-8

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