Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035932-03
Application #
2071910
Study Section
Special Emphasis Panel (SRC (25))
Project Start
1994-05-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Dentistry
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Kobayashi, Ryoki; Kohda, Tomoko; Kataoka, Kosuke et al. (2005) A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol 174:2190-5
Yoshino, Naoto; Lu, Fabien X-S; Fujihashi, Kohtaro et al. (2004) A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J Immunol 173:6850-7
Dohi, Taeko; Fujihashi, Kohtaro; Koga, Toshiya et al. (2004) CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165:1257-68
Dohi, Taeko; Fujihashi, Kohtaro; Koga, Toshiya et al. (2003) T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124:672-82
Hagiwara, Yukari; McGhee, Jerry R; Fujihashi, Keiko et al. (2003) Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol 170:1754-62
Kato, Hirotomo; Fujihashi, Kohtaro; Kato, Rie et al. (2003) Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions. Int Immunol 15:145-58
Kweon, Mi-Na; Yamamoto, Masafumi; Watanabe, Fumiko et al. (2002) A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. J Infect Dis 186:1261-9
Fujihashi, Kohtaro; Koga, Toshiya; van Ginkel, Frederik W et al. (2002) A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine 20:2431-8
Kato, H; Fujihashi, K; Kato, R et al. (2001) Oral tolerance revisited: prior oral tolerization abrogates cholera toxin-induced mucosal IgA responses. J Immunol 166:3114-21
Fujihashi, K; Dohi, T; Rennert, P D et al. (2001) Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci U S A 98:3310-5

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