Neutralization of Primary HIV-1 Viruses

Moore, John P.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI036082-03
• Application #: 2072149
• Study Section: AIDS and Related Research Study Section 1 (ARRA)
• Project Start: 1994-05-01
• Project End: 1998-01-31
• Budget Start: 1996-02-01
• Budget End: 1997-01-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Aaron Diamond AIDS Research Center
• DUNS #: 786658872
• City: New York
• State: NY
• Country: United States
• Zip Code: 10016

Publications

Ringe, Rajesh P; Ozorowski, Gabriel; Yasmeen, Anila et al. (2017) Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes. J Virol 91:

Acharya, Kriti; Rashad, Adel A; Moraca, Francesca et al. (2017) Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664. Proteins 85:843-851

Sullivan, Jonathan T; Sulli, Chidananda; Nilo, Alberto et al. (2017) High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers. J Virol 91:

Ringe, Rajesh P; Ozorowski, Gabriel; Rantalainen, Kimmo et al. (2017) Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers. J Virol 91:

Bird, Gregory H; Irimia, Adriana; Ofek, Gilad et al. (2014) Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat Struct Mol Biol 21:1058-67

Julien, Jean-Philippe; Lee, Jeong Hyun; Cupo, Albert et al. (2013) Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Proc Natl Acad Sci U S A 110:4351-6

Julien, Jean-Philippe; Sok, Devin; Khayat, Reza et al. (2013) Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog 9:e1003342

Matthews, Katie; Chung, Nancy P Y; Klasse, Per Johan et al. (2013) Clinical adjuvant combinations stimulate potent B-cell responses in vitro by activating dermal dendritic cells. PLoS One 8:e63785

Lyumkis, Dmitry; Julien, Jean-Philippe; de Val, Natalia et al. (2013) Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science 342:1484-90

Matthews, Katie; Chung, Nancy P Y; Klasse, Per Johan et al. (2012) Potent induction of antibody-secreting B cells by human dermal-derived CD14+ dendritic cells triggered by dual TLR ligation. J Immunol 189:5729-44