Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036186-02
Application #
2072304
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1995-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Farrow, Melissa A; Somasundaran, Mohan; Zhang, Chengsheng et al. (2005) Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. AIDS Res Hum Retroviruses 21:565-74
Mehle, Andrew; Goncalves, Joao; Santa-Marta, Mariana et al. (2004) Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. Genes Dev 18:2861-6
Mehle, Andrew; Strack, Bettina; Ancuta, Petronela et al. (2004) Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway. J Biol Chem 279:7792-8
Aires da Silva, Frederico; Santa-Marta, Mariana; Freitas-Vieira, Acilino et al. (2004) Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity. J Mol Biol 340:525-42
Goncalves, Joao; Silva, Frederico; Freitas-Vieira, Acilino et al. (2002) Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication. J Biol Chem 277:32036-45
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Yang, X; Chen, Y; Gabuzda, D (1999) ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. J Biol Chem 274:27981-8
Yang, X; Gabuzda, D (1998) Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein. J Biol Chem 273:29879-87
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