Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036293-03
Application #
2072479
Study Section
Experimental Virology Study Section (EVR)
Project Start
1994-08-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Aubert, Martine; Yoon, Miri; Sloan, Derek D et al. (2009) The virological synapse facilitates herpes simplex virus entry into T cells. J Virol 83:6171-83
Fan, Qing; Lin, Erick; Spear, Patricia G (2009) Insertional mutations in herpes simplex virus type 1 gL identify functional domains for association with gH and for membrane fusion. J Virol 83:11607-15
Fan, Qing; Lin, Erick; Satoh, Takeshi et al. (2009) Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed. J Virol 83:7384-90
Lin, Erick; Spear, Patricia G (2007) Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B. Proc Natl Acad Sci U S A 104:13140-5
Cheung, Timothy C; Humphreys, Ian R; Potter, Karen G et al. (2005) Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proc Natl Acad Sci U S A 102:13218-23
Struyf, Frank; Plate, Aileen E; Spear, Patricia G (2005) Deletion of the second immunoglobulin-like domain of nectin-1 alters its intracellular processing and localization and ability to mediate entry of herpes simplex virus. J Virol 79:3841-5
Yoon, Miri; Spear, Patricia G (2004) Random mutagenesis of the gene encoding a viral ligand for multiple cell entry receptors to obtain viral mutants altered for receptor usage. Proc Natl Acad Sci U S A 101:17252-7
Manoj, Sharmila; Jogger, Cheryl R; Myscofski, Dawn et al. (2004) Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Proc Natl Acad Sci U S A 101:12414-21
Zago, Anna; Jogger, Cheryl R; Spear, Patricia G (2004) Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion. Proc Natl Acad Sci U S A 101:17498-503
Spear, Patricia G; Longnecker, Richard (2003) Herpesvirus entry: an update. J Virol 77:10179-85

Showing the most recent 10 out of 22 publications