Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036552-03
Application #
2072899
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1994-09-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Kubota, S; Copeland, T D; Pomerantz, R J (1999) Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. Oncogene 18:1503-14
Jiang, A; Fisher, H; Pomerantz, R J et al. (1999) A genetically engineered spleen necrosis virus-derived retroviral vector that displays the HIV type 1 glycoprotein 120 envelope peptide. Hum Gene Ther 10:2627-36
Kubota, S; Pomerantz, R J (1998) A cis-acting peptide signal in human immunodeficiency virus type I Rev which inhibits nuclear entry of small proteins. Oncogene 16:1851-61
Ho, W Z; Lai, J P; Bouhamdan, M et al. (1998) Inhibition of HIV type 1 replication in chronically infected monocytes and lymphocytes by retrovirus-mediated gene transfer of anti-Rev single-chain variable fragments. AIDS Res Hum Retroviruses 14:1573-80
Inouye, R T; Du, B; Boldt-Houle, D et al. (1997) Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector. J Virol 71:4071-8
Duan, L; Zhu, M; Ozaki, I et al. (1997) Intracellular inhibition of HIV-1 replication using a dual protein- and RNA-based strategy. Gene Ther 4:533-43
Kubota, S; Hatanaka, M; Pomerantz, R J (1996) Nucleo-cytoplasmic redistribution of the HTLV-I Rex protein: alterations by coexpression of the HTLV-I p21x protein. Virology 220:502-7
Shaheen, F; Duan, L; Zhu, M et al. (1996) Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle. J Virol 70:3392-400
Pilkington, G R; Duan, L; Zhu, M et al. (1996) Recombinant human Fab antibody fragments to HIV-1 Rev and Tat regulatory proteins: direct selection from a combinatorial phage display library. Mol Immunol 33:439-50
Zhu, M; Duan, L; Pomerantz, R J (1996) TAR- and Tat-independent replication of human immunodeficiency virus type 1 in human hepatoma cells. AIDS Res Hum Retroviruses 12:1093-101

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