Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI038192-02S1
Application #
2646754
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1996-07-15
Project End
1999-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Bagley, Kenneth C; Abdelwahab, Sayed F; Tuskan, Robert G et al. (2006) Cholera toxin indirectly activates human monocyte-derived dendritic cells in vitro through the production of soluble factors, including prostaglandin E(2) and nitric oxide. Clin Vaccine Immunol 13:106-15
Bagley, Kenneth C; Abdelwahab, Sayed F; Tuskan, Robert G et al. (2005) Pasteurella multocida toxin activates human monocyte-derived and murine bone marrow-derived dendritic cells in vitro but suppresses antibody production in vivo. Infect Immun 73:413-21
Bagley, Kenneth C; Abdelwahab, Sayed F; Tuskan, Robert G et al. (2004) Calcium signaling through phospholipase C activates dendritic cells to mature and is necessary for the activation and maturation of dendritic cells induced by diverse agonists. Clin Diagn Lab Immunol 11:77-82
Bagley, K C; Shata, M T; Onyabe, D Y et al. (2003) Immunogenicity of DNA vaccines that direct the coincident expression of the 120 kDa glycoprotein of human immunodeficiency virus and the catalytic domain of cholera toxin. Vaccine 21:3335-41
Bagley, Kenneth C; Abdelwahab, Sayed F; Tuskan, Robert G et al. (2003) An enzymatically active a domain is required for cholera-like enterotoxins to induce a long-lived blockade on the induction of oral tolerance: new method for screening mucosal adjuvants. Infect Immun 71:6850-6
Bagley, Kenneth C; Abdelwahab, Sayed F; Tuskan, Robert G et al. (2002) Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway. J Leukoc Biol 72:962-9
Bagley, Kenneth C; Abdelwahab, Sayed F; Tuskan, Robert G et al. (2002) Cholera toxin and heat-labile enterotoxin activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cyclic AMP-dependent pathway. Infect Immun 70:5533-9
Carbonetti, N H; Tuskan, R G; Lewis, G K (2001) Stimulation of HIV gp120-specific cytolytic T lymphocyte responses in vitro and in vivo using a detoxified pertussis toxin vector. AIDS Res Hum Retroviruses 17:819-27
Shata, M T; Reitz Jr, M S; DeVico, A L et al. (2001) Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector. Vaccine 20:623-9
Shata, M T; Stevceva, L; Agwale, S et al. (2000) Recent advances with recombinant bacterial vaccine vectors. Mol Med Today 6:66-71

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