This is project to continue the study of host genetic resistance to HIV-1. The project evolved from early studies which showed that CD4 lymphocytes from random individuals possessed differential susceptibility to certain strains of T cell- trophic HIV. This appeared to be genetically determined because the susceptible or resistant phenotype was consistent for a given donor and a given HIV strain, and because it segregated in a family. Two years of work have demonstrated further that this differential susceptibility is genetically determined as judged by more family segregation studies, and that it appears to be a unique resistance which is a post-entry restriction of the virus and is not receptor-mediated. Other studies during this period have shown, also, that two cases of """"""""transient"""""""" HIV infection in adults are associated with this host lymphocyte resistance. Two new cohorts of high-risk individuals have been established and are currently under study to determine the frequency of transient infection and if host genetic resistance to T cell-trophic HIV strains is playing a role in both transient infection and in resistance to infection.
The specific aims of the project: (1) to map the viral determinant of this host resistance; (2) to map the resistance genes in the human genome; and (3) to demonstrate further whether these genes have a role in the human population in either preventing infection or retarding disease progression. In effect, the researchers in this project will characterize a third type of genetic resistance to HIV, adding to the HLA/TAP complex and the chemokine receptor polymorphisms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038530-06
Application #
6169290
Study Section
AIDS and Related Research Study Section 2 (ARRB)
Program Officer
Plaeger, Susan F
Project Start
1995-09-15
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
6
Fiscal Year
2000
Total Cost
$256,824
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555