Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038598-02
Application #
2075671
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Gachotte, D; Eckstein, J; Barbuch, R et al. (2001) A novel gene conserved from yeast to humans is involved in sterol biosynthesis. J Lipid Res 42:150-4
Kennedy, M A; Bard, M (2001) Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Biochim Biophys Acta 1517:177-89
Hughes, T R; Marton, M J; Jones, A R et al. (2000) Functional discovery via a compendium of expression profiles. Cell 102:109-26
Li, X; Routt, S M; Xie, Z et al. (2000) Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell 11:1989-2005
Gachotte, D; Sen, S E; Eckstein, J et al. (1999) Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. Proc Natl Acad Sci U S A 96:12655-60
Kennedy, M A; Barbuch, R; Bard, M (1999) Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1445:110-22
Gachotte, D; Barbuch, R; Gaylor, J et al. (1998) Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Proc Natl Acad Sci U S A 95:13794-9
Gachotte, D; Pierson, C A; Lees, N D et al. (1997) A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A 94:11173-8
Yang, H; Bard, M; Bruner, D A et al. (1996) Sterol esterification in yeast: a two-gene process. Science 272:1353-6
Arthington-Skaggs, B A; Crowell, D N; Yang, H et al. (1996) Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. FEBS Lett 392:161-5

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