Abstract

. The investigator proposes to identify and characterize genes from M. avium that are important in the pathogenicity of this organism through molecular and functional analyses of genomic DNA, recombinant molecules from genomic libraries and complementary DNA (cDNA) libraries produced from messenger RNA isolated from M. avium bacilii.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038672-04
Application #
2672605
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Project Start
1995-09-30
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Clark-Curtiss, Josephine E; Haydel, Shelley E (2003) Molecular genetics of Mycobacterium tuberculosis pathogenesis. Annu Rev Microbiol 57:517-49
Daigle, France; Hou, Joan Y; Clark-Curtiss, Josephine E (2002) Microbial gene expression elucidated by selective capture of transcribed sequences (SCOTS). Methods Enzymol 358:108-22
Hou, Joan Y; Graham, James E; Clark-Curtiss, Josephine E (2002) Mycobacterium avium genes expressed during growth in human macrophages detected by selective capture of transcribed sequences (SCOTS). Infect Immun 70:3714-26
Graham, J E; Clark-Curtiss, J E (1999) Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Proc Natl Acad Sci U S A 96:11554-9