Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI038758-01A1
Application #
2075866
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1996-02-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Kaneshiro, Edna S (2002) Sterol biosynthesis in Pneumocystis: unique steps that define unique targets. Drug Resist Updat 5:259-68
Giner, Jose-Luis; Zhao, Hui; Beach, David H et al. (2002) Comprehensive and definitive structural identities of Pneumocystis carinii sterols. J Lipid Res 43:1114-24
Kaneshiro, Edna S (2002) Is Pneumocystis a plant? J Eukaryot Microbiol 49:367-73
Kaneshiro, E S (2001) Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis? Drug Resist Updat 4:322-9
Amit, Z; Kaneshiro, E S (2001) Heterogeneity of Pneumocystis sterol profiles of samples from different sites in the same pair of lungs suggests coinfection by distinct organism populations. J Clin Microbiol 39:1137-9
Kaneshiro, E S; Sul, D; Hazra, B (2000) Effects of atovaquone and diospyrin-based drugs on ubiquinone biosynthesis in Pneumocystis carinii organisms. Antimicrob Agents Chemother 44:14-8
Kaneshiro, E S; Wyder, M A (2000) C27 to C32 sterols found in Pneumocystis, an opportunistic pathogen of immunocompromised mammals. Lipids 35:317-24
Kaneshiro, E S; Collins, M S; Cushion, M T (2000) Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. Antimicrob Agents Chemother 44:1630-8
Kaneshiro, E S; Collins, M; Cushion, M T (1999) Effects of sterol inhibitors on the ATP content of Pneumocystis carinii. J Eukaryot Microbiol 46:142S-143S
Kaneshiro, E S; Amit, Z; Swonger, M M et al. (1999) Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis. Proc Natl Acad Sci U S A 96:97-102

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