The primary goal of the proposed research is the development of a new synthetic route toward the vancomycin family of antibiotics. Specifically, the total synthesis of balhimycin will employ new versions of known methodology for the preparation of diaryl ether rings using a C2-symmetric triazene substrate. Other noteworthy applications include an intramolecular Diels-Alder addition. Degradation studies of balhimycin are expected to intercept and facilitate the total synthesis at a critical stage and to lead to the preparation of analogs for biological screening against drug resistant bacterial strains.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038893-02
Application #
2672620
Study Section
Special Emphasis Panel (ZRG3-BNP (01))
Project Start
1997-05-01
Project End
2001-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037