Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI039033-01
Application #
2076146
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1996-02-15
Project End
2000-01-31
Budget Start
1996-02-15
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Szempruch, Anthony J; Sykes, Steven E; Kieft, Rudo et al. (2016) Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell 164:246-257
Greene, Amy Styer; Hajduk, Stephen L (2016) Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei. J Biol Chem 291:3063-75
Sykes, Steven; Szempruch, Anthony; Hajduk, Stephen (2015) The krebs cycle enzyme ?-ketoglutarate decarboxylase is an essential glycosomal protein in bloodstream African trypanosomes. Eukaryot Cell 14:206-15
Harrington, John M; Nishanova, Tuiumkan; Pena, Savannah Rose et al. (2014) A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein. J Biol Chem 289:24811-20
Capewell, Paul; Clucas, Caroline; DeJesus, Eric et al. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathog 9:e1003686
DeJesus, E; Kieft, R; Albright, B et al. (2013) A single amino acid substitution in the group 1 Trypanosoma brucei gambiense haptoglobin-hemoglobin receptor abolishes TLF-1 binding. PLoS Pathog 9:e1003317
Stephens, Natalie A; Kieft, Rudo; Macleod, Annette et al. (2012) Trypanosome resistance to human innate immunity: targeting Achilles' heel. Trends Parasitol 28:539-45
Kieft, Rudo; Stephens, Natalie A; Capewell, Paul et al. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Mol Biochem Parasitol 183:8-14
Bullard, Whitney; Kieft, Rudo; Capewell, Paul et al. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors. Virulence 3:72-6
Harrington, John M; Scelsi, Chris; Hartel, Andreas et al. (2012) Novel African trypanocidal agents: membrane rigidifying peptides. PLoS One 7:e44384

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