Abstract

Neurological cytokines have shown tremendous therapeutic potential for preventing or delaying blindness. Several of these cytokines stimulate the receptor gp130. Stimulation with either leukemia inhibitory factor (LIF) or ciliary neurotrophic factor (CNTF) has three profound effects on retinal cells: inhibition of differentiation; neuroprotection from retinal degeneration; and reduced light response of photoreceptors. Despite the interest in these effects, little is known about the role of gp130 in normal retinal development or its role in preventing photoreceptor death. In this study we will use tissue specific inactivation of gp130 to address three important questions. 1.What is the role gp130 in normal differentiation of the retina? 2. Is gp130 expression in photoreceptors or Muller cells responsible for neuroprotection and function loss? 3. Is the PI3K/Akt pathway responsible for gp130 induced neuroprotection?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY016459-03
Application #
7385032
Study Section
Biology and Diseases of the Posterior Eye Study Section (BDPE)
Program Officer
Mariani, Andrew P
Project Start
2006-02-02
Project End
2010-01-31
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
3
Fiscal Year
2008
Total Cost
$277,004
Indirect Cost

  Institution

Name
University of Oklahoma Health Sciences Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117

  Publications

Brown, Emily E; Lewin, Alfred S; Ash, John D (2018) Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration. Adv Exp Med Biol 1074:11-17
Xu, Lei; Kong, Li; Wang, Jiangang et al. (2018) Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium. Proc Natl Acad Sci U S A 115:10475-10480
Hooper, Marcus J; Wang, Jiangang; Browning, Robert et al. (2018) Damage-associated molecular pattern recognition is required for induction of retinal neuroprotective pathways in a sex-dependent manner. Sci Rep 8:9115
Hooper, Marcus J; Ash, John D (2018) Müller Cell Biological Processes Associated with Leukemia Inhibitory Factor Expression. Adv Exp Med Biol 1074:479-484
Abrahan, Carolina; Ash, John D (2016) Erratum to: The Potential Use of PGC-1? and PGC-1? to Protect the Retina by Stimulating Mitochondrial Repair. Adv Exp Med Biol 854:E1
Abrahan, Carolina; Ash, John D (2016) The Potential Use of PGC-1? and PGC-1? to Protect the Retina by Stimulating Mitochondrial Repair. Adv Exp Med Biol 854:403-9
Xu, Lei; Ash, John D (2016) The Role of AMPK Pathway in Neuroprotection. Adv Exp Med Biol 854:425-30
Ildefonso, Cristhian J; Jaime, Henrique; Brown, Emily E et al. (2016) Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide. Invest Ophthalmol Vis Sci 57:372-86
Reagan, Alaina; Gu, Xiaowu; Hauck, Stefanie M et al. (2016) Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol 854:411-8
Fu, Suhua; Zhu, Meili; Ash, John D et al. (2014) Investigating the role of retinal Müller cells with approaches in genetics and cell biology. Adv Exp Med Biol 801:401-5

Showing the most recent 10 out of 24 publications