Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI039098-01
Application #
2076206
Study Section
Immunobiology Study Section (IMB)
Project Start
1996-03-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Sasada, Tetsuro; Touma, Maki; Chang, Hsiu-Ching et al. (2002) Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. J Exp Med 195:1419-31
Witte, T; Spoerl, R; Chang, H C (1999) The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers. Cell Immunol 191:90-6
Kern, P; Hussey, R E; Spoerl, R et al. (1999) Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers. J Biol Chem 274:27237-43
Saito, N G; Chang, H C; Paterson, Y (1999) Recognition of an MHC class I-restricted antigenic peptide can be modulated by para-substitution of its buried tyrosine residues in a TCR-specific manner. J Immunol 162:5998-6008
Kern, P S; Teng, M K; Smolyar, A et al. (1998) Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity 9:519-30
Ghendler, Y; Teng, M K; Liu, J H et al. (1998) Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95:10061-6
Ghendler, Y; Smolyar, A; Chang, H C et al. (1998) One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop. J Exp Med 187:1529-36
Witte, T; Smolyar, A; Spoerl, R et al. (1997) Major histocompatibility complex recognition by immune receptors: differences among T cell receptor versus antibody interactions with the VSV8/H-2Kb complex. Eur J Immunol 27:227-33
Ghendler, Y; Hussey, R E; Witte, T et al. (1997) Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol 27:2279-89
Khandekar, S S; Brauer, P P; Naylor, J W et al. (1997) Affinity and kinetics of the interactions between an alphabeta T-cell receptor and its superantigen and class II-MHC/peptide ligands. Mol Immunol 34:493-503

Showing the most recent 10 out of 12 publications