Pharmacokinetic Studies of Intracellular Zdv in Children

Rodriguez, Jose F.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI039191-02
• Application #: 2076292
• Study Section: Special Emphasis Panel (SRC (47))
• Project Start: 1995-09-30
• Project End: 2000-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Puerto Rico Med Sciences
• Department: Pharmacology
• Type: Schools of Pharmacy
• City: San Juan
• State: PR
• Country: United States
• Zip Code: 00936

Publications

Meléndez, Margarita; Rosario, Osvaldo; Zayas, Beatriz et al. (2009) HPLC-MS/MS method for the intracellular determination of ribavirin monophosphate and ribavirin triphosphate in CEM ss cells. J Pharm Biomed Anal 49:1233-40

Melendez, Margarita; Blanco, Raul; Delgado, Wilfredo et al. (2006) Lack of evidence for in vivo transformation of zidovudine triphosphate to stavudine triphosphate in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 50:835-40

Rodman, J H (2001) Design of antiretroviral clinical trials for HIV-1 infected pregnant women and their newborn infants. Semin Perinatol 25:170-6

Font, E; Rosario, O; Santana, J et al. (1999) Determination of zidovudine triphosphate intracellular concentrations in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals by tandem mass spectrometry. Antimicrob Agents Chemother 43:2964-8

Font, E; Lasanta, S; Rosario, O et al. (1998) Analysis of antiretroviral nucleosides by electrospray ionization mass spectrometry and collision induced dissociation. Nucleosides Nucleotides 17:845-53