Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI039563-01
Application #
2076625
Study Section
Immunobiology Study Section (IMB)
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206
Shapiro, Gary S; Ellison, Misoo C; Wysocki, Lawrence J (2003) Sequence-specific targeting of two bases on both DNA strands by the somatic hypermutation mechanism. Mol Immunol 40:287-95
Jena, Prasanna K; Smith, Diana S; Zhang, Xianghua et al. (2003) Somatic translocation and differential expression of Ig mu transgene copies implicate a role for the Igh locus in memory B cell development. Mol Immunol 39:885-97
Shapiro, Gary S; Aviszus, Katja; Murphy, James et al. (2002) Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation. J Immunol 168:2302-6
Shapiro, Gary S; Wysocki, Lawrence J (2002) DNA target motifs of somatic mutagenesis in antibody genes. Crit Rev Immunol 22:183-200
Tumas-Brundage, K M; Notidis, E; Heltemes, L et al. (2001) Predominance of a novel splenic B cell population in mice expressing a transgene that encodes multireactive antibodies: support for additional heterogeneity of the B cell compartment. Int Immunol 13:475-84
Jena, P K; Liu, A H; Smith, D S et al. (2000) Sequence heterogeneity in Ig kappa transcripts from single B lymphocytes. Mol Immunol 37:265-72
Shapiro, G S; Aviszus, K; Ikle, D et al. (1999) Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition. J Immunol 163:259-68
Wysocki, L J; Liu, A H; Jena, P K (1998) Somatic mutagenesis and evolution of memory B cells. Curr Top Microbiol Immunol 229:105-31
Wysocki, L J; Zhang, X; Smith, D S et al. (1998) Somatic origin of T-cell epitopes within antibody variable regions: significance to monoclonal therapy and genesis of systemic autoimmune disease. Immunol Rev 162:233-46
Bonorino, C; Nardi, N B; Zhang, X et al. (1998) Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161:5210-6

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