Crystal Structure of Toxoplasma Gondii Hgprt

Borhani, David W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 1R01AI039952-01A1
• Application #: 2076902
• Study Section: AIDS and Related Research Study Section 4 (ARRD)
• Project Start: 1996-07-01
• Project End: 2000-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Southern Research Institute
• DUNS #: 006900526
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35205

Publications

White, E L; Ross, L J; Davis, R L et al. (2000) The two toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase isozymes form heterotetramers. J Biol Chem 275:19218-23

Heroux, A; White, E L; Ross, L J et al. (2000) Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis. Structure 8:1309-18

Heroux, A; White, E L; Ross, L J et al. (1999) Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with XMP, pyrophosphate, and two Mg(2+) ions bound: insights into the catalytic mechanism. Biochemistry 38:14495-506

Heroux, A; White, E L; Ross, L J et al. (1999) Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex. Biochemistry 38:14485-94