The PI proposes experiments to understand the noncytolytic inhibition of HIV mediated by CD8+ T cells. The goals are to: a) identify the factors, b) define the mechanisms, c) identify viral determinants which allow susceptibility. The PI will study whether inhibition occurs at integration or inhibition of expression. He also will characterize the factors from the Herpes-virus saimiri line that he has developed and examine the chemokines recently reported to be involved. The overall goal is to understand the basis for CD8 HIV inhibitory activity and may facilitate therapies for HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040017-02
Application #
2429511
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1996-07-01
Project End
2001-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705