Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI040227-01
Application #
2077119
Study Section
Special Emphasis Panel (ZRG2-ALY (01))
Project Start
1996-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Vettermann, Christian; Timblin, Greg A; Lim, Vivian et al. (2015) The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination. PLoS One 10:e0113824
Degner, Stephanie C; Verma-Gaur, Jiyoti; Wong, Timothy P et al. (2011) CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A 108:9566-71
Guo, Chunguang; Yoon, Hye Suk; Franklin, Andrew et al. (2011) CTCF-binding elements mediate control of V(D)J recombination. Nature 477:424-30
Sukumar, Selvakumar; Schlissel, Mark S (2011) Receptor editing as a mechanism of B cell tolerance. J Immunol 186:1301-2
Vettermann, Christian; Schlissel, Mark S (2010) Allelic exclusion of immunoglobulin genes: models and mechanisms. Immunol Rev 237:22-42
Curry, John D; Schlissel, Mark S (2008) RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination. Nucleic Acids Res 36:5750-62
Hewitt, Susannah L; Farmer, Deborah; Marszalek, Katarzyna et al. (2008) Association between the Igk and Igh immunoglobulin loci mediated by the 3'Igk enhancer induces 'decontraction'of the Igh locus in pre-B cells. Nat Immunol 9:396-404
Bates, Jamie Geier; Cado, Dragana; Nolla, Hector et al. (2007) Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination. J Exp Med 204:3247-56
Curry, John D; Schulz, Danae; Guidos, Cynthia J et al. (2007) Chromosomal reinsertion of broken RSS ends during T cell development. J Exp Med 204:2293-303
Curry, John D; Geier, Jamie K; Schlissel, Mark S (2005) Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis. Nat Immunol 6:1272-9

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