The principal investigator proposes to employ a pathogenic chimeric simian-human immunodeficiency virus (SHIV) to determine whether passive immunization can protect against mucosa (vaginal) or needle stick exposure to HIV. Two sources of SHIV/HIV-neutralizing antibody will be evaluated: a monoclonal anti-HIV gp120 (mAb b12) or polyconal anti-SHIV pooled sera from infected rhesus macaques with low virus burdens. Passive immunotherapy will be initiated either 12 hours pre- or 12 hours post intravaginal SHIV exposure and 10 pre- or 1 or 12 hours post subcutaneous injection. The establishment of infection and disease progression will then be monitored over a 12 month period and compared with animals not receiving passive immunization. The results of these studies are designed to establish whether passive immunization with virus neutralizing antibody can prevent or abort SHIV infection or influence the progression of SHIV disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040372-03
Application #
2837468
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Program Officer
Bradac, James A
Project Start
1996-12-01
Project End
1999-11-30
Budget Start
1998-12-01
Budget End
1999-11-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Kansas
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
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