The proposed research involves a 5-year systematic study of ticks on a worldwide basis including morphological, cladistic, molecular and genetic analyses. Ticks transmit more pathogens to humans and their animals than any other arthropods, and systematic studies of these disease transmitters are essential to the understanding of vector/host relationships and vectorial capacity. The basis for these systematic investigations in the U.S. National Tick Collection, the world's largest, its companion library on ticks and tick-borne diseases, and computer access to complete biosystematic data on over 122,000 tick collections from throughout the globe. These systematic resources are unique, allowing this type of research nowhere else.
Specific aim one will be the study of the primary vectors of Lyme disease, i.e., the Ixodes (I.) ricinus complex of ticks on a global basis. These 15 known or potential vector species will be studied morphologically, morphometrically, and at the molecular level to investigate relationships among the species. Hybridization of Nearctic and Palearctic species will be conducted in Switzerland and/or Russia.
Specific aim two will be preparation of a monograph on all 55 species of larval Ixodidae known from the United States. This monograph will fill a significant void, given the importance of ixodid larvae in pathogen maintenance, especially via transovarial transmission from female ticks. Both line drawings and SEM photomicrographs will be used in conjunction with keys. Complete data on hosts, geographical distribution, and medical and veterinary importance for each species will be presented.
Specific aim three will be a monographic revision of the 44 known and approximately 20 undescribed species of the genus Ixodes from in Central and South America. Little information is available on Borrelia and Ehrlichia spp from Central and South America. We intend to check archived Ixodes species from this area using PCR methods.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040729-04
Application #
6373593
Study Section
Special Emphasis Panel (ZRG1-TMP (01))
Program Officer
Aultman, Kathryn S
Project Start
1999-09-01
Project End
2004-06-30
Budget Start
2002-09-01
Budget End
2003-06-30
Support Year
4
Fiscal Year
2002
Total Cost
$159,498
Indirect Cost
Name
Georgia Southern University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
063828383
City
Statesboro
State
GA
Country
United States
Zip Code
30460
Oguge, N O; Durden, L A; Keirans, J E et al. (2009) Ectoparasites (sucking lice, fleas and ticks) of small mammals in southeastern Kenya. Med Vet Entomol 23:387-92
Labruna, Marcelo B; Keirans, James E; Camargo, Luis Marcelo A et al. (2005) Amblyomma latepunctatum, a valid tick species (Acari: Ixodidae) long misidentified with both amblyomma incisum and Amblyomma scalpturatum. J Parasitol 91:527-41
Xu, Guang; Fang, Quentin Q; Sun, Yi et al. (2005) Hard tick calreticulin (CRT) gene coding regions have only one intron with conserved positions and variable sizes. J Parasitol 91:1326-31
Morshed, Muhammad G; Scott, John D; Fernando, Keerthi et al. (2005) Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus. J Parasitol 91:780-90
Gonzalez-Acuna, D; Beldomenico, P M; Venzal, J M et al. (2005) Reptile trade and the risk of exotic tick introductions into southern South American countries. Exp Appl Acarol 35:335-9
Guglielmone, Alberto A; Venzal, Jose M; Amico, Guillermo et al. (2004) Description of the nymph and larva and redescription of the female of Ixodes neuquenensis Ringuelet, 1947 (Acari: Ixodidae), a parasite of the endangered Neotropical marsupial Dromiciops gliroides Thomas (Microbiotheria: Microbiotheriidae). Syst Parasitol 57:211-9
Scott, John D; Fernando, Keerthi; Durden, Lance A et al. (2004) Lyme disease spirochete, Borrelia burgdorferi, endemic in epicenter at Turkey Point, Ontario. J Med Entomol 41:226-30
Xu, Guang; Fang, Quentin Q; Keirans, James E et al. (2004) Cloning and sequencing of putative calreticulin complementary DNAs from four hard tick species. J Parasitol 90:73-8
Durden, Lance A; Ellis, Barbara A; Banks, Craig W et al. (2004) Ectoparasites of gray squirrels in two different habitats and screening of selected ectoparasites for bartonellae. J Parasitol 90:485-9
Durden, Lance A; Polur, Ram N; Nims, Todd et al. (2004) Ectoparasites and other epifaunistic arthropods of sympatric cotton mice and golden mice: comparisons and implications for vector-borne zoonotic diseases. J Parasitol 90:1293-7

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