The investigators have initiated studies to elucidate the polyamine metabolic pathways of the microsporidia as potential targets for drug design. Preliminary in vitro data suggests that inhibition of this pathway inhibits microsporidial replication. The purpose of this proposal is to investigate the usefulness of drugs designed to inhibit this pathway and thus develop a target for effective treatment of microsporidian infections in man.
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| Bacchi, C J; Yarlett, N (2002) Polyamine metabolism as chemotherapeutic target in protozoan parasites. Mini Rev Med Chem 2:553-63 |
| Bacchi, C J; Lane, S; Weiss, L M et al. (2001) Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi. J Eukaryot Microbiol 48:374-81 |
| Zou, Y; Wu, Z; Sirisoma, N et al. (2001) Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett 11:1613-7 |
