Abstract

The proposed studies will examine the biological consequences of multiple resistance mutations on viral replication and pathogenicity, using the SCID-hu mouse system. This system will be used to test the hypothesis that multiply resistant strains of HIV are less evolutionarily fit. In addition, the effect of antiviral selective pressure and/or mutations in reverse transcriptase on viral recombination will be studied in vivo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI041924-03
Application #
6170644
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Bridges, Sandra H
Project Start
1998-05-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
3
Fiscal Year
2000
Total Cost
$188,998
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Levy, David N; Aldrovandi, Grace M; Kutsch, Olaf et al. (2004) Dynamics of HIV-1 recombination in its natural target cells. Proc Natl Acad Sci U S A 101:4204-9