Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI042181-02
Application #
6171094
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1999-04-15
Project End
2002-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
2
Fiscal Year
2000
Total Cost
$299,450
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Cross, Alan (2016) Endotoxin: Back to the Future. Crit Care Med 44:450-1
Cross, Alan S (2014) Anti-endotoxin vaccines: back to the future. Virulence 5:219-25
Cross, Alan S (2010) Development of an anti-endotoxin vaccine for sepsis. Subcell Biochem 53:285-302
Chen, Wilbur H; Basu, Subhendu; Bhattacharjee, Apurba K et al. (2010) Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors. Innate Immun 16:322-32
Chen, Wilbur H; Kang, Tae Jin; Bhattacharjee, Apurba K et al. (2008) Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia. Innate Immun 14:269-78
Cross, Alan S; Chen, Wilbur H; Levine, Myron M (2008) A case for immunization against nosocomial infections. J Leukoc Biol 83:483-8
Cross, Alan S; Opal, Steven M; Palardy, John E et al. (2003) Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects. Vaccine 21:4576-87
Opal, S M; Palardy, J E; Parejo, N et al. (2001) Lipopolyamines as a therapeutic strategy in experimental Gram-negative bacterial sepsis. J Endotoxin Res 7:35-8
Cross, A S; Opal, S M; Warren, H S et al. (2001) Active immunization with a detoxified Escherichia coli J5 lipopolysaccharide group B meningococcal outer membrane protein complex vaccine protects animals from experimental sepsis. J Infect Dis 183:1079-86