Abstract

This proposal addresses inhibitors of Candida spp aspartic proteases as antifungal agents.
The aims are to develop rapid screening procedures of Candida proteases from plant sources, evaluate plant extracts for protease inhibition, isolate and structurally characterize inhibitors from active plant extracts, characterize the mechanisms of inhibition of purified active natural products and design and synthesize second-generation inhibitors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI042500-01
Application #
2542920
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Program Officer
Johnson, George S
Project Start
1998-03-01
Project End
2001-02-28
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Mississippi
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
University
State
MS
Country
United States
Zip Code
38677

  Publications

Zhang, Zhizhen; ElSohly, Hala N; Jacob, Melissa R et al. (2002) Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum. J Nat Prod 65:979-85
Zhang, Zhizhen; ElSohly, Hala N; Jacob, Melissa R et al. (2002) Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta Med 68:49-54
Zhang, Zhizhen; ElSohly, Hala N; Jacob, Melissa R et al. (2002) New sesquiterpenoids from the root of Guatteria multivenia. J Nat Prod 65:856-9
Li, X C; Jacob, M R; Pasco, D S et al. (2001) Phenolic compounds from Miconia myriantha inhibiting Candida aspartic proteases. J Nat Prod 64:1282-5
Zhang, Z; ElSohly, H N; Jacob, M R et al. (2001) New indole alkaloids from the bark of Nauclea orientalis. J Nat Prod 64:1001-5