The goal of this proposal is to understand the nature of transcription factor binding, apoptosis and the role of Nef and Nef-binding proteins in the avoidance of killing by MHC class I-restricted CTLs. The role of Nef in down regulating MHC class I expression will be assessed using techniques that allow characterization by flow cytometric analysis of events in primary and cultured cells with high-titered mutant or wild-type viruses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI042549-05
Application #
6475498
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Wassef, Nabila M
Project Start
1997-12-01
Project End
2002-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
5
Fiscal Year
2002
Total Cost
$285,625
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
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