Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI043469-05
Application #
6756596
Study Section
Immunobiology Study Section (IMB)
Program Officer
Winter, David B
Project Start
1999-03-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
5
Fiscal Year
2004
Total Cost
$317,000
Indirect Cost
Name
Tufts University
Department
Pathology
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Mele, Deanna A; Sampson, James F; Huber, Brigitte T (2011) Th17 differentiation is the default program for DPP2-deficient T-cell differentiation. Eur J Immunol 41:1583-93
Danilov, Alexey V; Danilova, Olga V; Brown, Jennifer R et al. (2010) Dipeptidyl peptidase 2 apoptosis assay determines the B-cell activation stage and predicts prognosis in chronic lymphocytic leukemia. Exp Hematol 38:1167-77
Mele, Deanna A; Bista, Pradeep; Baez, Diana Velez et al. (2009) Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. Cell Cycle 8:2425-34
Rockwell, Karen R; Huber, Brigitte T (2009) Biologically distinct conformations of Bcl-x can be resolved using 2D isoelectric focusing. Mol Immunol 46:1605-12
Danilova, Olga V; Tai, Albert K; Mele, Deanna A et al. (2009) Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity. Endocrinology 150:5240-8
Bista, Pradeep; Mele, Deanna A; Baez, Diana Velez et al. (2008) Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1. Mol Immunol 45:3618-23
Danilova, Olga; Li, Bei; Szardenings, A Katrin et al. (2007) Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. Bioorg Med Chem Lett 17:507-10
Danilov, Alexey V; Klein, Andreas K; Lee, Henry J et al. (2005) Differential control of G0 programme in chronic lymphocytic leukaemia: a novel prognostic factor. Br J Haematol 128:472-81
Seward, Robert J; von Haller, Priska D; Aebersold, Ruedi et al. (2003) Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis. Mol Immunol 39:983-93
Denis, Maria C; Huber, Brigitte T (2003) Native and recombinant interleukin-2, two functionally distinct molecules. Mol Immunol 40:279-86

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