Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI043695-01A1
Application #
2873456
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (01))
Program Officer
Plaeger, Susan F
Project Start
1999-06-01
Project End
2002-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Jayakumar, Prerana; Berger, Irina; Autschbach, Frank et al. (2005) Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1. J Virol 79:5220-6
Roy, Ann-Marie; Schweighardt, Becky; Eckstein, Lauren A et al. (2005) Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells. J Acquir Immune Defic Syndr 40:267-75
Jekle, Andreas; Keppler, Oliver T; De Clercq, Erik et al. (2003) In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells. J Virol 77:5846-54
Sherman, Michael P; de Noronha, Carlos M C; Eckstein, Lauren A et al. (2003) Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages. J Virol 77:7582-9
Jekle, Andreas; Schramm, Birgit; Jayakumar, Prerana et al. (2002) Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence. J Virol 76:6966-73
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Penn, M L; Myers, M; Eckstein, D A et al. (2001) Primary and recombinant HIV type 1 strains resistant to protease inhibitors are pathogenic in mature human lymphoid tissues. AIDS Res Hum Retroviruses 17:517-23
Eckstein, D A; Sherman, M P; Penn, M L et al. (2001) HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells. J Exp Med 194:1407-19
Eckstein, D A; Penn, M L; Korin, Y D et al. (2001) HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues. Immunity 15:671-82
Grivel, J C; Penn, M L; Eckstein, D A et al. (2000) Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue. J Virol 74:5347-51

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