Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI045169-05
Application #
6682773
Study Section
Special Emphasis Panel (ZRG1-BM-2 (03))
Program Officer
Korpela, Jukka K
Project Start
1999-05-01
Project End
2005-04-30
Budget Start
2003-05-01
Budget End
2005-04-30
Support Year
5
Fiscal Year
2003
Total Cost
$277,856
Indirect Cost
Name
University of South Florida
Department
Biochemistry
Type
Schools of Medicine
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612
Newton, Catherine A; Chou, Ping-Jen; Perkins, Izabella et al. (2009) CB(1) and CB(2) cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection. J Neuroimmune Pharmacol 4:92-102
Chou, Ping-Jen Joe; Newton, Catherine A; Perkins, Izabella et al. (2008) Suppression of dendritic cell activation by anthrax lethal toxin and edema toxin depends on multiple factors including cell source, stimulus used, and function tested. DNA Cell Biol 27:637-48
Newton, Cathy A; Perkins, Izabella; Widen, Raymond H et al. (2007) Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice. Infect Immun 75:146-51
Lu, Tangying; Newton, Cathy; Perkins, Izabella et al. (2006) Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. J Pharmacol Exp Ther 319:269-76
Lu, Tangying; Newton, Cathy; Perkins, Izabella et al. (2006) Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila. Eur J Pharmacol 532:170-7
Newton, Catherine A; Lu, Tangying; Nazian, Stanley J et al. (2004) The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J Leukoc Biol 76:854-61
Yamamoto, Yoshimasa; Matsunaga, Kazuto; Friedman, Herman (2004) Protective effects of green tea catechins on alveolar macrophages against bacterial infections. Biofactors 21:119-21
Matsunaga, Kazuto; Yamaguchi, Hiroyuki; Klein, Thomas W et al. (2003) Legionella pneumophila suppresses macrophage interleukin-12 production by activating the p42/44 mitogen-activated protein kinase cascade. Infect Immun 71:6672-5
Klein, Thomas W; Newton, Cathy; Larsen, Kellie et al. (2003) The cannabinoid system and immune modulation. J Leukoc Biol 74:486-96
Friedman, Herman; Newton, Catherine; Klein, Thomas W (2003) Microbial infections, immunomodulation, and drugs of abuse. Clin Microbiol Rev 16:209-19

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