Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI045378-05
Application #
6632090
Study Section
Special Emphasis Panel (ZRG1-AARR-2 (01))
Program Officer
Wassef, Nabila M
Project Start
1999-03-01
Project End
2004-06-30
Budget Start
2003-03-01
Budget End
2004-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$466,665
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Boyd, David F; Peterson, Dylan; Haggarty, Beth S et al. (2015) Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer. J Virol 89:894-907
Parrish, Nicholas F; Gao, Feng; Li, Hui et al. (2013) Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci U S A 110:6626-33
Parker, Zahra F; Iyer, Shilpa S; Wilen, Craig B et al. (2013) Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5. J Virol 87:2401-11
Parrish, Nicholas F; Wilen, Craig B; Banks, Lauren B et al. (2012) Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin ?4?7. PLoS Pathog 8:e1002686
Acharya, Priyamvada; Dogo-Isonagie, Cajetan; LaLonde, Judith M et al. (2011) Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. ACS Chem Biol 6:1069-77
Del Prete, Gregory Q; Leslie, George J; Haggarty, Beth et al. (2010) Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist. J Virol 84:8777-89
Hoxie, James A (2010) Toward an antibody-based HIV-1 vaccine. Annu Rev Med 61:135-52
Agrawal-Gamse, Caroline; Lee, Fang-Hua; Haggarty, Beth et al. (2009) Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4. J Virol 83:11005-15
Nolan, Katrina M; Del Prete, Gregory Q; Jordan, Andrea P O et al. (2009) Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor. J Virol 83:3798-809
Nolan, Katrina M; Jordan, Andrea P O; Hoxie, James A (2008) Effects of partial deletions within the human immunodeficiency virus type 1 V3 loop on coreceptor tropism and sensitivity to entry inhibitors. J Virol 82:664-73

Showing the most recent 10 out of 18 publications