Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI045587-01
Application #
2881948
Study Section
Experimental Immunology Study Section (EI)
Program Officer
Quill, Helen R
Project Start
1999-07-01
Project End
2004-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Immune Disease Institute, Inc.
Department
Type
DUNS #
115524410
City
Boston
State
MA
Country
United States
Zip Code
02115
Dotiwala, Farokh; Sen Santara, Sumit; Binker-Cosen, Andres Ariel et al. (2017) Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell 171:1125-1137.e11
Thomas, Marshall P; Liu, Xing; Whangbo, Jennifer et al. (2015) Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep 11:1079-89
Thomas, Marshall P; Whangbo, Jennifer; McCrossan, Geoffrey et al. (2014) Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol 192:5390-7
Walch, Michael; Dotiwala, Farokh; Mulik, Sachin et al. (2014) Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell 157:1309-23
Rajani, Danielle K; Walch, Michael; Martinvalet, Denis et al. (2012) Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A 109:8688-93
Yan, Nan; O'Day, Elizabeth; Wheeler, Lee Adam et al. (2011) HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A 108:9244-9
Yan, Nan; Lieberman, Judy (2011) Gaining a foothold: how HIV avoids innate immune recognition. Curr Opin Immunol 23:21-8
Lieberman, Judy (2010) Granzyme A activates another way to die. Immunol Rev 235:93-104
Yan, Nan; Regalado-Magdos, Ashton D; Stiggelbout, Bart et al. (2010) The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 11:1005-13
Thiery, Jerome; Walch, Michael; Jensen, Danielle K et al. (2010) Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol Chapter 3:Unit3.37

Showing the most recent 10 out of 33 publications