Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI047760-01
Application #
6149693
Study Section
Special Emphasis Panel (ZRG1-AARR-2 (01))
Program Officer
Litterst, Charles L
Project Start
2000-04-15
Project End
2005-03-31
Budget Start
2000-04-15
Budget End
2001-03-31
Support Year
1
Fiscal Year
2000
Total Cost
$318,939
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tomescu, Costin; Tebas, Pablo; Montaner, Luis J (2017) IFN-? augments natural killer-mediated antibody-dependent cellular cytotoxicity of HIV-1-infected autologous CD4+ T cells regardless of major histocompatibility complex class 1 downregulation. AIDS 31:613-622
Tomescu, Costin; Tebas, Pablo; Montaner, Luis J (2017) IFN-? augments NK-mediated antibody-dependent cellular cytotoxicity (ADCC) of HIV-1 infected autologous CD4+ T cells regardless of MHC-I downregulation. AIDS :
Tomescu, Costin; Mavilio, Domenico; Montaner, Luis J (2015) Lysis of HIV-1-infected autologous CD4+ primary T cells by interferon-alpha-activated NK cells requires NKp46 and NKG2D. AIDS 29:1767-73
Gekonge, Bethsebah; Bardin, Matthew C; Montaner, Luis J (2015) Short communication: Nitazoxanide inhibits HIV viral replication in monocyte-derived macrophages. AIDS Res Hum Retroviruses 31:237-41
Gekonge, Bethsebah; Raymond, Andrea D; Yin, Xiangfan et al. (2012) Retinoblastoma protein induction by HIV viremia or CCR5 in monocytes exposed to HIV-1 mediates protection from activation-induced apoptosis: ex vivo and in vitro study. J Leukoc Biol 92:397-405
Raymond, Andrea D; Gekonge, Bethsebah; Giri, Malavika S et al. (2010) Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia. J Leukoc Biol 88:589-96
Giri, Malavika S; Nebozyhn, Michael; Raymond, Andrea et al. (2009) Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance. J Immunol 182:4459-70
Tomescu, Costin; Chehimi, Jihed; Maino, Vernon C et al. (2009) Retention of viability, cytotoxicity, and response to IL-2, IL-15, or IFN-alpha by human NK cells after CD107a degranulation. J Leukoc Biol 85:871-6
Papasavvas, Emmanouil; Moore, Elizabeth C; Sun, Junwei et al. (2008) HIV type 1 viremia on ART is positively associated with polyclonal T cell proliferation in subjects with T cell IFN-gamma secretion levels comparable to those of uninfected subjects. AIDS Res Hum Retroviruses 24:1203-8
Tomescu, Costin; Chehimi, Jihed; Maino, Vernon C et al. (2007) NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells. J Immunol 179:2097-104

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