Despite promising anti-retroviral treatments for fighting HIV, poor adherence to medication ranks as a major cause of treatment failure and emerging drug resistance. The proposed anthropological project will examine African Americans living with HIV and their cultural experience of adhering to HAART over time. It will contribute data on adherence practice within the larger context of the patient's life. It will also advance our knowledge about African Americans, a group with the highest incidence and death rates from HIV. The goal of the proposed 5-year study is to identify and describe the evolution of patient adherence practices and understandings as located in the wider setting of daily living with HIV. We propose to follow the lives of 150 HIV+ African Americans in Detroit, each for three years using a two group design to represent key periods over the span of the HAART patient experience. Building on the lived experience perspective, we will provide in-depth data on personal and cultural beliefs, motives, and rationales associated with adherence and non-adherence practices. One strength of the study design is that it allows us to examine how the patient's own definition of the course, stages and critical transitions in adherence relate to relationships, experiences, and influences and culturally salient sources of support for and barriers to sustained HAART adherence. The study will contribute to understanding the challenges of and resources for adhering to complex medical regimens over time by studying HIV+ African Americans adhering to HAART. The improved understanding of adherence patterns and variability may help clinicians to anticipate adherence difficulties and develop interventions to enhance those factors that support adherence. Basic knowledge created by the proposed study may lead to research that integrates the patient's perspective into effective interventions for improving adherence. The study is characterized by the innovative use of emerging paradigms of the social science approach to improving adherence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI049113-04
Application #
6752451
Study Section
Special Emphasis Panel (ZRG1-AARR-8 (02))
Program Officer
Joseph, Moriane
Project Start
2001-07-10
Project End
2006-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
4
Fiscal Year
2004
Total Cost
$645,999
Indirect Cost
Name
Wayne State University
Department
Social Sciences
Type
Schools of Arts and Sciences
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
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Sankar, Andrea; Neufeld, Stewart; Berry, Rico et al. (2011) Cultural rationales guiding medication adherence among African American with HIV/AIDS. AIDS Patient Care STDS 25:547-55
Sankar, A P; Nevedal, D C; Neufeld, S et al. (2007) What is a missed dose? Implications for construct validity and patient adherence. AIDS Care 19:775-80
Sankar, Andrea; Wunderlich, Tracy; Neufeld, Stewart et al. (2007) Sero-positive African Americans'beliefs about alcohol and their impact on anti-retroviral adherence. AIDS Behav 11:195-203
Rohn, Edward J; Sankar, Andrea; Hoelscher, Diane C et al. (2006) How do social-psychological concerns impede the delivery of care to people with HIV? Issues for dental education. J Dent Educ 70:1038-42