Haemophilus Hap-mediated Microcolony Formation

St. Geme, Joseph W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI049322-02
• Application #: 6690982
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Program Officer: Klein, David L
• Project Start: 2003-01-01
• Project End: 2007-12-31
• Budget Start: 2004-01-01
• Budget End: 2004-12-31
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $267,750

Institution

• Name: Washington University
• Department: Pediatrics
• Type: Schools of Medicine
• DUNS #: 068552207
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Spahich, Nicole A; Hood, Derek W; Moxon, E Richard et al. (2012) Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter. J Bacteriol 194:1815-22

Meng, Guoyu; Spahich, Nicole; Kenjale, Roma et al. (2011) Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation. EMBO J 30:3864-74

Sukupolvi-Petty, Soila; Grass, Susan; St Geme 3rd, Joseph W (2006) The Haemophilus influenzae Type b hcsA and hcsB gene products facilitate transport of capsular polysaccharide across the outer membrane and are essential for virulence. J Bacteriol 188:3870-7

O'Neill, Joshua M; St Geme 3rd, Joseph W; Cutter, David et al. (2003) Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas. J Clin Microbiol 41:3064-9