Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI049719-12
Application #
6872158
Study Section
Special Emphasis Panel (ZRG1-IFCN-2 (01))
Program Officer
Johnson, David R
Project Start
1993-08-01
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2007-03-31
Support Year
12
Fiscal Year
2005
Total Cost
$302,504
Indirect Cost
Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Ashcraft, Kathleen A; Hunzeker, John; Bonneau, Robert H (2008) Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism. Psychoneuroendocrinology 33:951-63
Freeman, Michael L; Sheridan, Brian S; Bonneau, Robert H et al. (2007) Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. J Immunol 179:322-8
Elftman, Michael D; Norbury, Christopher C; Bonneau, Robert H et al. (2007) Corticosterone impairs dendritic cell maturation and function. Immunology 122:279-90
Nair, Aji; Hunzeker, John; Bonneau, Robert H (2007) Modulation of microglia and CD8(+) T cell activation during the development of stress-induced herpes simplex virus type-1 encephalitis. Brain Behav Immun 21:791-806
Nair, Aji; Bonneau, Robert H (2006) Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroimmunol 171:72-85
Erin, Nuray; Boyer, Philip J; Bonneau, Robert H et al. (2004) Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res 24:1003-9
Khanna, Kamal M; Bonneau, Robert H; Kinchington, Paul R et al. (2003) Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18:593-603
Anglen, Crystal S; Truckenmiller, M E; Schell, Todd D et al. (2003) The dual role of CD8+ T lymphocytes in the development of stress-induced herpes simplex encephalitis. J Neuroimmunol 140:13-27