Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI049945-02
Application #
6760900
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Kirkham, Perry M
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$266,875
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Surgery
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Zhang, Li; You, Junping; Sidhu, Jitinderpal et al. (2013) Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways. Transplantation 96:782-90
Skelton, T Spencer; Tejpal, Neelam; Gong, Yongquan et al. (2012) Allochimeric molecules and mechanisms in abrogation of cardiac allograft rejection. J Heart Lung Transplant 31:73-84
Lisik, Wojciech; Gong, Yongquan; Tejpal, Neelam et al. (2010) Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model. Genesis 48:8-19
Skelton, T Spencer; Tejpal, Neelam; Gong, Yongquan et al. (2010) Downregulation of RhoA and changes in T cell cytoskeleton correlate with the abrogation of allograft rejection. Transpl Immunol 23:185-93
Liu, Dahai; Shen, Xiu-Da; Zhai, Yuan et al. (2009) Intragraft selection of the T cell receptor repertoire by class I MHC sequences in tolerant recipients. PLoS One 4:e6076
Lisik, Wojciech; Tejpal, Neelam; Gong, Yongquan et al. (2009) Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. PLoS One 4:e8020
Semiletova, Natalya V; Shen, Xiu-Da; Feldman, Daniel M et al. (2007) Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains. Cell Immunol 248:48-58
Semiletova, Natalya V; Shen, Xiu-Da; Baibakov, Boris et al. (2005) Inhibition of chronic rejection by antibody induced vascular accommodation in fully allogeneic heart allografts. Transplantation 80:1535-40
Liu, D; Shen, X-D; Fang, Z et al. (2005) Identification of early tolerance regulator genes induced by allochimeric therapy using microarray-based genomewide scan. Transplant Proc 37:1942-3
Semiletova, N V; Shen, X-D; Feldman, D M et al. (2005) Donor MHC class I peptides in conjunction with self-epitopes induce donor-specific tolerance in a dose-dependent manner but unable to abrogate chronic rejection. Transplant Proc 37:1937-9