: The long-term objective of our research program is to design situation- and/or site-specific strategies for the suppression of environmentally mediated infectious diseases. The immediate issue addressed here is to determine if the intensity of transmission of Schistosoma japonicum can be predictably diminished by using a mathematical model, based on both local data and general knowledge of the transmission cycle, to design effective interventions. The specific alms of this project are: 1.Model Development: to further develop our model of schistosomiasis transmission, based on exposure-related risk groups, to more effectively utilize site-specific field data typically collected in China as well as data on spatial factors relevant to disease transmission now easily obtained using GPS technology. 2. Use the Model for Design: to design effective control programs in four to six villages selected from two sites. The first phase of this work will be to collect the standard field data set in three villages in the Changqiu Mountains west of Chengdu to supplement that available from the Qionghai Lake villages with the objective of full site-specific calibration of the refined model. 3. Implement the Designs: we propose to implement the designs resulting from Specific Aim 2 and evaluate the results in these villages, if sustainable environmental interventions using traditional methods do not emerge, we will determine whether the impediments to success are rooted in inadequate knowledge, technological limitations, or agricultural practices.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI050612-01
Application #
6415018
Study Section
Special Emphasis Panel (ZRG1-TMP (01))
Program Officer
Aultman, Kathryn S
Project Start
2002-06-01
Project End
2007-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
1
Fiscal Year
2002
Total Cost
$326,687
Indirect Cost
Name
University of California Berkeley
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Carlton, Elizabeth J; Hsiang, Michelle; Zhang, Yi et al. (2010) The impact of Schistosoma japonicum infection and treatment on ultrasound-detectable morbidity: a five-year cohort study in Southwest China. PLoS Negl Trop Dis 4:e685
Hsiang, Michelle S; Carlton, Elizabeth J; Zhang, Yi et al. (2010) Use of ultrasonography to evaluate Schistosoma japonicum-related morbidity in children, Sichuan Province, China, 2000-2007. Am J Trop Med Hyg 82:103-11
Spear, Robert C; Hubbard, A (2010) Parameter estimation and site-specific calibration of disease transmission models. Adv Exp Med Biol 673:99-111
Remais, Justin; Zhong, Bo; Carlton, Elizabeth J et al. (2009) Model approaches for estimating the influence of time-varying socio-environmental factors on macroparasite transmission in two endemic regions. Epidemics 1:213-20
Remais, Justin; Chen, Lin; Seto, Edmund (2009) Leveraging rural energy investment for parasitic disease control: schistosome ova inactivation and energy co-benefits of anaerobic digesters in rural China. PLoS One 4:e4856
Gurarie, David; Seto, Edmund Y W (2009) Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivities. J R Soc Interface 6:495-508
Remais, Justin; Liang, Song; Spear, Robert C (2008) Coupling hydrologic and infectious disease models to explain regional differences in schistosomiasis transmission in southwestern China. Environ Sci Technol 42:2643-9
Seto, Edmund Y W; Knapp, Freyja; Zhong, Bo et al. (2007) The use of a vest equipped with a global positioning system to assess water-contact patterns associated with schistosomiasis. Geospat Health 1:233-41
Seto, Edmund Y W; Lee, Yu J; Liang, Song et al. (2007) Individual and village-level study of water contact patterns and Schistosoma japonicum infection in mountainous rural China. Trop Med Int Health 12:1199-209
Liang, Song; Seto, Edmund Y W; Remais, Justin V et al. (2007) Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western China. Proc Natl Acad Sci U S A 104:7110-5

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