Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI051342-02
Application #
6683633
Study Section
Immunobiology Study Section (IMB)
Program Officer
Macchiarini, Francesca
Project Start
2002-12-01
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$331,875
Indirect Cost
Name
Ohio State University
Department
Pathology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Zheng, Xincheng; Zhang, Huiming; Yin, Lijie et al. (2008) Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation. PLoS One 3:e2703
May Jr, Kenneth F; Chang, Xing; Zhang, Huiming et al. (2007) B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells. J Immunol 178:1542-52
Zuo, Tao; Wang, Lizhong; Morrison, Carl et al. (2007) FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129:1275-86
Chang, Xing; Chen, Li; Wen, Jing et al. (2006) Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Clin Immunol 121:274-85
Wang, Yin; Liu, Yan; Wu, Cindy et al. (2006) Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell 10:179-90
Gao, Jian-Xin; Chang, Xing; Zheng, Xincheng et al. (2004) A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen. Int Immunol 16:1403-9
Zheng, Xincheng; Gao, Jian-Xin; Chang, Xing et al. (2004) B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus. J Immunol 173:2253-61
Sarma, Supria; Bai, Xue-Feng; Liu, Jin-qing et al. (2003) On the role of unmutated antigens in tumor rejection in mice with unperturbed T-cell repertoires. Cancer Res 63:6051-5