Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI051507-02
Application #
6693327
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Program Officer
Rogers, Martin J
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$335,170
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Bezsonova, Irina; Rujan, Iulian; Bobenchik, April M et al. (2013) (1)H, (13)C, and (15)N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum. Biomol NMR Assign 7:17-20
Augagneur, Yoann; Wesolowski, Donna; Tae, Hyun Seop et al. (2012) Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Proc Natl Acad Sci U S A 109:6235-40
Bobenchik, April M; Augagneur, Yoann; Hao, Bing et al. (2011) Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy. FEMS Microbiol Rev 35:609-19
González-Bulnes, Patricia; Bobenchik, April M; Augagneur, Yoann et al. (2011) PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity. J Biol Chem 286:28940-7
Downie, Megan J; El Bissati, Kamal; Bobenchik, April M et al. (2010) PfNT2, a permease of the equilibrative nucleoside transporter family in the endoplasmic reticulum of Plasmodium falciparum. J Biol Chem 285:20827-33
Bobenchik, April M; Choi, Jae-Yeon; Mishra, Arunima et al. (2010) Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay. BMC Biochem 11:4
Downie, Megan J; Kirk, Kiaran; Mamoun, Choukri Ben (2008) Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum. Eukaryot Cell 7:1231-7
Reynolds, Jennifer M; Takebe, Sachiko; Choi, Jae-Yeon et al. (2008) Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum. J Biol Chem 283:7894-900
Witola, William Harold; El Bissati, Kamal; Pessi, Gabriella et al. (2008) Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects. J Biol Chem 283:27636-43
El Bissati, Kamal; Downie, Megan J; Kim, Seong-Kyoun et al. (2008) Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum. Mol Biochem Parasitol 161:130-9

Showing the most recent 10 out of 13 publications