Development of a Cytomegalovirus Vaccine

Spector, Deborah Hye

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI051557-02
• Application #: 6685920
• Study Section: Special Emphasis Panel (ZRG1-VACC (01))
• Program Officer: Beisel, Christopher E
• Project Start: 2002-12-01
• Project End: 2007-11-30
• Budget Start: 2003-12-01
• Budget End: 2004-11-30
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $380,000

Institution

• Name: University of California San Diego
• Department: Biology
• Type: Schools of Arts and Sciences
• DUNS #: 804355790
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92093

Publications

Morello, Christopher S; Kelley, Laura A; Munks, Michael W et al. (2007) DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge. J Virol 81:7766-75

Morello, Christopher S; Ye, Ming; Hung, Stephanie et al. (2005) Systemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challenge. J Virol 79:159-75

Ye, Ming; Morello, Christopher S; Spector, Deborah H (2004) Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization. J Virol 78:11233-45