Abstract

This proposal outlines a project designed to meet the requirements for an Asthma and Allergic Diseases Research (AADRC). Role of the IgE-FceRi network in allergic inflammation. All are united by the central theme that three major steps lead to the development of the asthmatic disease: the initial immunization phase against allergens (step 1) the amplification of the Th2 response (step 2), and the development of the effector response and asthma (step3). The hypothesis of this project is that cells expressing high affinity IgE receptor in the form of alphagamma2 contributes to the regulation of the IgE immune response (step 2) and participates in the effector functions of the IgE- FcepsilonRI network in vivo (step 3).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI051644-03
Application #
6609699
Study Section
Special Emphasis Panel (ZAI1-NBS-I (M3))
Program Officer
Bocek, Petr
Project Start
2001-09-30
Project End
2006-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
3
Fiscal Year
2003
Total Cost
$382,500
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Chandraker, Anil; Huurman, Volkert; Hallett, Karen et al. (2005) CTLA-4 is important in maintaining long-term survival of cardiac allografts. Transplantation 79:897-903