Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI051990-14
Application #
6512261
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Meegan, James M
Project Start
1989-03-01
Project End
2005-05-31
Budget Start
2002-07-01
Budget End
2003-05-31
Support Year
14
Fiscal Year
2002
Total Cost
$342,351
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Konopka, Jennifer L; Thompson, Joseph M; Whitmore, Alan C et al. (2009) Acute infection with venezuelan equine encephalitis virus replicon particles catalyzes a systemic antiviral state and protects from lethal virus challenge. J Virol 83:12432-42
Thompson, Joseph M; Nicholson, Michael G; Whitmore, Alan C et al. (2008) Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. J Immunol 181:574-85
Thompson, Joseph M; Whitmore, Alan C; Staats, Herman F et al. (2008) The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. Vaccine 26:4998-5003
Thompson, Joseph M; Whitmore, Alan C; Staats, Herman F et al. (2008) Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. Vaccine 26:4267-75
Montgomery, Stephanie A; Johnston, Robert E (2007) Nuclear import and export of Venezuelan equine encephalitis virus nonstructural protein 2. J Virol 81:10268-79
Moran, Timothy P; Burgents, Joseph E; Long, Brian et al. (2007) Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice. Vaccine 25:6604-12
Konopka, Jennifer L; Penalva, Luiz O; Thompson, Joseph M et al. (2007) A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo. PLoS Pathog 3:e199
Thompson, Joseph M; Whitmore, Alan C; Konopka, Jennifer L et al. (2006) Mucosal and systemic adjuvant activity of alphavirus replicon particles. Proc Natl Acad Sci U S A 103:3722-7
Montgomery, Stephanie A; Berglund, Peter; Beard, Clayton W et al. (2006) Ribosomal protein S6 associates with alphavirus nonstructural protein 2 and mediates expression from alphavirus messages. J Virol 80:7729-39