Abstract

Memory T cells contain large amounts of mRNA for certain chemokines, including RANTES, MIP-1alpha and MIP-1beta. This mRNA is not translated, however, unless the cells are stimulated via their T cell receptors. Experiments will be performed to find out what portion of the chemokine mRNAs is involved in the silencing and which signaling pathways induced by T cell receptor engagement release the mRNAs from translational inhibition. Memory T cells may use these stores of preformed chemokine mRNA for very rapid responses to antigen. A protocol will be established to find out whether this is so, in animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI052225-04
Application #
6916461
Study Section
Allergy and Immunology Study Section (ALY)
Program Officer
Rathbun, Gary
Project Start
2002-08-01
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
4
Fiscal Year
2005
Total Cost
$266,878
Indirect Cost

  Institution

Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206

  Publications

Clambey, Eric T; Collins, Bernard; Young, Mary H et al. (2013) The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells. PLoS One 8:e57435
Rubtsov, Anatoly V; Rubtsova, Kira; Kappler, John W et al. (2013) TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice. Immunol Res 55:210-6
Marrack, Philippa; Kappler, John W (2012) Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med 2:a007765
Rubtsov, Anatoly V; Rubtsova, Kira; Fischer, Aryeh et al. (2011) Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c? B-cell population is important for the development of autoimmunity. Blood 118:1305-15
MacLeod, Megan K L; David, Alexandria; McKee, Amy S et al. (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol 186:2889-96
Munks, Michael W; McKee, Amy S; Macleod, Megan K et al. (2010) Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood 116:5191-9
MacLeod, Megan K L; Kappler, John W; Marrack, Philippa (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology 130:10-5
MacLeod, Megan K L; Clambey, Eric T; Kappler, John W et al. (2009) CD4 memory T cells: what are they and what can they do? Semin Immunol 21:53-61
McKee, Amy S; Munks, Michael W; MacLeod, Megan K L et al. (2009) Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 183:4403-14
MacLeod, Megan K L; McKee, Amy; Crawford, Frances et al. (2008) CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A 105:14521-6

Showing the most recent 10 out of 37 publications