Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI052266-03
Application #
6999070
Study Section
Special Emphasis Panel (ZRG1-ALTX-4 (02))
Program Officer
Rothermel, Annette L
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-10-15
Budget End
2004-12-31
Support Year
3
Fiscal Year
2004
Total Cost
$243,701
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Yarur, Andres J; Jain, Anjali; Quintero, Maria A et al. (2018) Inflammatory Cytokine Profile in Crohn's Disease Nonresponders to Optimal Antitumor Necrosis Factor Therapy. J Clin Gastroenterol :
Fukata, Masayuki; Shang, Limin; Santaolalla, Rebeca et al. (2011) Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis 17:1464-73
Hernandez, Yasmin; Sotolongo, John; Breglio, Keith et al. (2010) The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. BMC Gastroenterol 10:82
Fukata, Masayuki; Abreu, Maria T (2009) Pathogen recognition receptors, cancer and inflammation in the gut. Curr Opin Pharmacol 9:680-7
Ungaro, Ryan; Fukata, Masayuki; Hsu, David et al. (2009) A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol 296:G1167-79
Fukata, Masayuki; Hernandez, Yasmin; Conduah, Daisy et al. (2009) Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm Bowel Dis 15:997-1006
Fukata, Masayuki; Chen, Anli; Vamadevan, Arunan S et al. (2007) Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133:1869-81