Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI052267-02
Application #
6764025
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Van de Verg, Lillian L
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$370,450
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Nguyen, Deanna D; Wurbel, Marc-Andre; Goettel, Jeremy A et al. (2012) Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology 143:719-729.e2
Zhao, Xixing; Ross, Erik J; Wang, Yanyan et al. (2012) Nfkb1 inhibits LPS-induced IFN-? and IL-12 p40 production in macrophages by distinct mechanisms. PLoS One 7:e32811
Fox, J G; Ge, Z; Whary, M T et al. (2011) Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol 4:22-30
Yang, Huei-Ting; Wang, Yanyan; Zhao, Xixing et al. (2011) NF-?B1 inhibits TLR-induced IFN-? production in macrophages through TPL-2-dependent ERK activation. J Immunol 186:1989-96
Erdman, S E; Rao, V P; Poutahidis, T et al. (2009) Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. Proc Natl Acad Sci U S A 106:1027-32
Murphy, C G; Glickman, J N; Tomczak, K et al. (2008) Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. Mucosal Immunol 1:297-308
Wang, Yanyan; Rickman, Barry H; Poutahidis, Theofilos et al. (2008) c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol 180:8118-25
Poutahidis, Theofilos; Haigis, Kevin M; Rao, Varada P et al. (2007) Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis 28:2614-23
Gadjeva, Mihaela; Wang, Yanyan; Horwitz, Bruce H (2007) NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol 37:2509-17
Horwitz, Bruce H (2007) The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice. Inflamm Bowel Dis 13:490-500

Showing the most recent 10 out of 14 publications