Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI052395-02
Application #
6702295
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Koshy, Rajen
Project Start
2003-02-15
Project End
2008-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
2
Fiscal Year
2004
Total Cost
$298,875
Indirect Cost
Name
New York Medical College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041907486
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Mousseau, G; Kota, S; Takahashi, V et al. (2011) Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase. J Gen Virol 92:101-11
Frick, David N; Ginzburg, Olya; Lam, Angela M I (2010) A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities. Methods Mol Biol 587:223-33
Belon, Craig A; High, Yoji D; Lin, Tse-I et al. (2010) Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor. Biochemistry 49:1822-32
Meng, Xiao; Zhou, Yajing; Lee, Ernest Y C et al. (2010) The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. Biochemistry 49:3545-54
Belon, Craig A; Frick, David N (2009) Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C. Future Virol 4:277-293
Heck, Julie A; Meng, Xiao; Frick, David N (2009) Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. Biochem Pharmacol 77:1173-80
Belon, Craig A; Frick, David N (2009) Fuel specificity of the hepatitis C virus NS3 helicase. J Mol Biol 388:851-64
Meng, Xiao; Zhou, Yajing; Zhang, Sufang et al. (2009) DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers. Nucleic Acids Res 37:647-57
Neumann-Haefelin, Christoph; Frick, David N; Wang, Jing Jing et al. (2008) Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level. J Virol 82:3438-51
Belon, Craig A; Frick, David N (2008) Monitoring helicase activity with molecular beacons. Biotechniques 45:433-40, 442

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