Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI055604-02
Application #
6795562
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Program Officer
Coyne, Philip Edward
Project Start
2003-09-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$345,947
Indirect Cost
Name
University of Washington
Department
Genetics
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hawkins, Vivian N; Suzuki, Stephanie M; Rungsihirunrat, Kanchana et al. (2009) Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase. Am J Trop Med Hyg 81:348-55
Hawkins, Vivian N; Auliff, Alyson; Prajapati, Surendra Kumar et al. (2008) Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase. Malar J 7:72
Certain, Laura K; Briceno, Marnie; Kiara, Steven M et al. (2008) Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006. J Infect Dis 197:1743-51
Sandefur, Conner I; Wooden, Jason M; Quaye, Isaac K et al. (2007) Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro. Mol Biochem Parasitol 154:1-5
Rungsihirunrat, Kanchana; Na-Bangchang, Kesara; Hawkins, Vivian N et al. (2007) Sensitivity to antifolates and genetic analysis of Plasmodium vivax isolates from Thailand. Am J Trop Med Hyg 76:1057-65
Hawkins, Vivian N; Joshi, Hema; Rungsihirunrat, Kanchana et al. (2007) Antifolates can have a role in the treatment of Plasmodium vivax. Trends Parasitol 23:213-22
Certain, Laura K; Sibley, Carol H (2007) Plasmodium falciparum: a novel method for analyzing haplotypes in mixed infections. Exp Parasitol 115:233-41
Sibley, Carol Hopkins; Ringwald, Pascal (2006) A database of antimalarial drug resistance. Malar J 5:48
Hapuarachchi, Hapuarachchige C; Dayanath, Meegoda Y D; Bandara, Kandeyaye Bandaralage A T et al. (2006) Point mutations in the dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum and resistance to sulfadoxine-pyrimethamine in Sri Lanka. Am J Trop Med Hyg 74:198-204
Watkins, William M; Sibley, Carol Hopkins; Hastings, Ian M (2005) The search for effective and sustainable treatments for Plasmodium falciparum malaria in Africa: a model of the selection of resistance by antifolate drugs and their combinations. Am J Trop Med Hyg 72:163-73

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